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Can exercise-induced neurogenesis protect against the deterioration of neuronal function with develops with age in a mouse model of Alzheimer's disease (AD) - Dublin
The cognitive impairment that is a hallmark of AD is associated with neuroinflammatory changes which accompany accumulation of amyloid protein and that ultimately lead to neuronal dysfunction and loss. The evidence suggests that a reduction in neurogenesis contributes to age-related cognitive deficits in disorders such as AD, hence interventions that increase neurogenesis provide a promising therapeutic strategy. In this project, we will assess whether chronic, life-long exercise protects against the cognitive impairment and loss of synaptic function observed in APP/PS1 mice. Sedentary mice and those allowed access to a running wheel will be assessed at intervals for cognitive performance in hippocampal-dependent learning tasks. At old age, brain tissue will be harvested for assessment for neurogenesis and neuroinflammatory changes. We predict that boosting the neurogenic capacity of the brain will mitigate the loss of synaptic and cognitive function in this model of AD. ... (Training Available in Dublin by Irish Universities Association (IUA)) Can exercise-induced neurogenesis protect against the deterioration of neuronal function with develops with age in a mouse model of Alzheimer's disease (AD)in Dublin
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